神经药理学报

神经药理学报 ›› 2025, Vol. 15 ›› Issue (1): 55-.DOI: 10.3969/j.issn.2095-1396.2025.01.009

• 综述 • 上一篇    

外泌体在靶向药物递送与疾病治疗中的应用与机制研究

要祎冉，张健东，李炜   

  1. 1. 河北北方学院药学院，张家口，075000，中国 

    2. 河北省神经损伤与修复重点实验室，承德，067000，中国

  • 出版日期:2025-02-26 发布日期:2025-06-20
  • 通讯作者: 李炜，教授，研究生导师；E-mail：leewei318@163.com
  • 作者简介:要祎冉，22级药学专业本科在读
  • 基金资助:
    河北省神经损伤与修复重点实验室开放课题（No.NJKF202402），河北北方学院面上项目（No.XJ2024021）

Application and Mechanism Study of Exosomes in Targeted Drug Delivery and Disease Therapy

YAO Yi-ran, ZHANG Jian-dong, LI Wei   

  1. 1. College of Pharmacy, Hebei North University, Zhangjiakou, 075000, China 

    2. Hebei Key Laboratory of Nerve Injury and Repair, Chengde, 067000, China

  • Online:2025-02-26 Published:2025-06-20

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摘要：

作为内源性纳米囊泡，外泌体通过运输细胞内的蛋白质、核酸及脂质等促进细胞通信交流，因具有良好 的生物相容性、高稳定性以及对组织和细胞的特异性靶向等优点，是理想的药物递送载体。此外，外泌体在神经 系统疾病、肿瘤以及心血管疾病诊断和治疗中的应用机制也得到深入研究。该文综述了外泌体在靶向药物递送 中的应用以及外泌体在治疗疾病中的机制研究，旨在为未来的研究和临床应用提供理论指导。

关键词: 外泌体, 药物载体, 靶向治疗

Abstract:

As endogenous nanovesicles, exosomes promote cellular communication and exchange by transporting intracellular proteins, nucleic acids and lipids, and are ideal drug delivery vehicles due to their good biocompatibility, high stability and specific targeting to tissues and cells. In addition, the application mechanism of exosomes in the diagnosis and treatment of neurological diseases, tumors, and cardiovascular diseases has also been thoroughly studied. In this paper, we reviewed the application of exosomes in targeted drug delivery and the mechanism study of exosomes in the treatment of diseases, aiming to provide theoretical guidance for future research and clinical application.

Key words: exosomes, drug carriers, targeted therapy

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