神经药理学报

神经药理学报 ›› 2026, Vol. 16 ›› Issue (3): 50-.DOI: 10.3969/j.issn.2095-1396.2026.03.007

• 研究论文 • 上一篇    下一篇

胃肠安丸对 IBS-D 青壮年患者的临床疗效及对血清 TNF-α、IL-6 的影响

王语嘉，韩宝娟   

  1. 1. 河北北方学院研究生学院，张家口，075000，中国 

    2. 邢台市人民医院消化内科，邢台，054000，中国

  • 出版日期:2026-06-26 发布日期:2026-08-05
  • 通讯作者: 韩宝娟，主任医师，硕士研究生导师；研究方向：肠易激综合征
  • 作者简介:王语嘉，2023 级硕士研究生；研究方向：肠易激综合征

Clinical Efficacy of Weichang'an Wan in Young and MiddleAged Patients with IBS-D and Its Effects on Serum TNF-α and IL-6

WANG Yu-jia，HAN Bao-juan   

  1. 1. Graduate School of Hebei North University, Zhangjiakou, 075000, China 

    2. Department of Gastroenterology, Xingtai People's Hospital, Xingtai, 054000, China

  • Online:2026-06-26 Published:2026-08-05

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摘要：

目的：探究胃肠安丸对腹泻型肠易激综合征（diarrhea-predominant irritable bowel syndrome，IBS-D）青 壮年患者的临床疗效及其对血清白细胞介素 -6（interleukin-6，IL-6）、肿瘤坏死因子 -α（tumor necrosis factor-α， TNF-α）的影响。方法：2024-06—2025-06 就诊于邢台市人民医院消化内科门诊 IBS-D 患者 90 例，年龄 15~44 岁， 采用随机生成器将其分为观察组和对照组各 45 例。观察组口服胃肠安丸，对照组口服匹维溴铵，对比两组患者 用药前后的临床疗效、IL-6 及 TNF-α 水平的变化，比较两组 IBS 患者生活质量评分（irritable bowel syndrome quality of life，IBS-QOL）、IBS 病情严重程度评分（irritable bowel syndrome severity scoring system，IBS-SSS）、汉 密尔顿焦虑量表（Hamilton anxiety scale，HAMA）及汉密尔顿抑郁量表（Hamilton depression scale，HAMD）评 分的变化。结果：观察组总有效率高于对照组（P<0.05），治疗后观察组 TNF-α 水平低于对照组（P<0.05），IBSQOL 评分高于对照组，HAMA、HAMD 评分均低于对照组（P<0.05）。结论：胃肠安丸能有效改善 IBS-D 青壮年 患者的临床症状，改善患者炎症水平，改善情绪，提高生活质量。

关键词: 腹泻型肠易激综合征, 胃肠安丸, 青壮年, 情绪障碍, 炎症, 生活质量

Abstract:

Objective: To investigate the clinical efficacy of Weichang'an Wan in young adults with diarrhea-predominant irritable bowel syndrome (IBS-D) and its effects on serum IL-6 and TNF-α levels. Methods: Ninety patients aged 15~44 years who met the IBS-D diagnostic criteria were selected and randomly divided into an observation group(45 cases) and a control group(45 cases) using a random generator. The observation group received oral Weichang'an Wan, while the control group received oral pinaverium bromide. Clinical efficacy, serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels before and after treatment were compared between the two groups. Additionally, changes in irritable bowel syndrome quality of life （IBS-QOL）, irritable bowel syndrome severity scoring system （IBS-SSS）, Hamilton anxiety scale (HAMA), and Hamilton depression scale (HAMD) scores before and after treatment were compared. Results: The total effective rate of the observation group was higher than that of thecontrol group (P<0.05). After treatment, the TNF-α level in the observation group was lower than that in the control group (P<0.05). The IBS-QOL score of the observation group was higher than that of the control group, while the HAMA and HAMD scores were lower than those of the control group (P<0.05). Conclusion: Weichang'an Wan can effectively improve clinical symptoms in young and middle-aged IBS-D patients, reduce inflammation levels, alleviate emotional distress, and enhance quality of life.

Key words: diarrhea-predominant irritable bowel syndrome, weichang'an wan, young adults, emotional disorders, inflammation, quality of life

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