神经药理学报

神经药理学报 ›› 2026, Vol. 16 ›› Issue (3): 15-.DOI: 10.3969/j.issn.2095-1396.2026.03.002

• 研究论文 • 上一篇    下一篇

肉桂醛对小鼠鲍曼不动杆菌肺炎的保护作用

马冉，蔡亭亭，郭晓如，邓洁华，马玉昕，王刚生   

  1. 1. 河北省胸科医院皮肤科，石家庄，050047，中国 

    2. 河北医科大学第二医院感染科，石家庄，050000，中国 

    3. 河北医科大学第二医院皮肤科，石家庄，050000，中国

  • 出版日期:2026-06-26 发布日期:2026-08-04
  • 通讯作者: 王刚生，教授，硕士研究生导师；研究方向：真菌和真菌病研究
  • 作者简介:马冉，主治医师，硕士研究生；研究方向：感染性疾病的研究
  • 基金资助:
    河北省自然科学基金资助项目（No.H2013206316）

The Protective Effect of Cinnamaldehyde on Bacterial Pneumonia in Mice Caused by Acinetobacter Baumannii

JIA Li-fang, LI Lu-lu, REN Yu-fan, ZHANG Si-bo, YOU Si-han, WANG Jing   

  1. 1. Dermatology Department, Hebei Chest Hospital, Shijiazhuang, 050047, China 

    2. Infectious Diseases Department, Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China 

    3. Dermatology Department, Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China

  • Online:2026-06-26 Published:2026-08-04

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摘要：

目 的：研究肉桂醛 (cinnamaldehyde，CA) 对免疫抑制 BALB/c 小鼠鲍曼不动杆菌 (acinetobacter baumannii，AB) 肺炎的保护作用，为研发新型抗菌药物提供理论依据。方法：180 只免疫抑制 AB 肺炎小鼠按照 随机数表法分为 6 组，每组 30 只，分别为 CA 高剂量组（240 mg·kg-1·d-1）、CA 中剂量组（120 mg·kg-1·d-1）、CA 低剂 量组（60 mg·kg-1·d-1）、替加环素（tigecycline，TIG）阳性对照组（120 mg·kg-1·d-1）、吐温盐水阴性对照组（10 mL·kg-1·d-1）、 模型组。除了模型组不给药外，其余 5 组均连续灌胃给药 14 d。停药 24 h 后采集各组小鼠肺组织样本进行血平 板细菌培养、组织病理切片（HE 染色）检查及观察小鼠生存情况。结果：细菌培养显示：CA 治疗组的细菌清除率 分别为高剂量组 80%（24/30）、中剂量组 73.33%（22/30）、低剂量组 50.00%（15/30），TIG 阳性对照组 46.66%（14/30）， 吐温盐水阴性对照组 6.66%（2/30），模型组 10.00%（3/30）。CA 各治疗组与吐温盐水阴性对照组、模型组比较（P <0.001），与 TIG 阳性对照组比较（P<0.05）。病理切片显示：CA 中、高剂量组，肺泡结构趋于正常，炎性细胞浸润 明显减少。CA 低剂量组，肺组织轻度损伤，仍有炎性细胞浸润和肺泡结构异常。TIG 阳性对照组，肺组织病理 损伤较模型组有所减轻，但仍可见一定程度的炎性浸润和结构紊乱。模型组和吐温盐水阴性对照组，肺组织呈 现显著的病理损伤、大量炎性细胞浸润。小鼠存活率：CA 高剂量组 80%（24/30）、中剂量组 73.33％（22/30）、低剂 量组 50.00%（15/30）、TIG 阳性对照组 46.66%（14/30）、吐温盐水阴性对照组 6.66%（2/30）、模型组（10.00%（3/30）。 结论：CA 组（高、中剂量）连续用药 14 d，治疗小鼠鲍曼不动杆菌肺炎具有较好的抗菌作用和组织修复作用，并能 显著提高小鼠存活率，且 CA 优于 TIG。该研究将为 CA 治疗鲍曼不动杆菌肺炎的新药研发提供理论依据。

关键词: 肉桂醛, 鲍曼不动杆菌, 肺炎, 抗菌作用, 组织修复作用

Abstract:

Objective: To study cinnamaldehyde (cinnamaldehyde, CA) against acinetobacter baumannii in immunosuppressed BALB/c mice (acinetobacter baumannii, AB) pneumonia, providing theoretical basis for the development of new antibacterial drugs.Methods: 180 immunosuppressed AB pneumonia mice were randomly divided into 6 groups, 30 mice in each group, respectively CA high dose group (240 mg·kg-1·d-1), CA medium dose group (120 mg·kg-1·d-1), CA low dose group (60 mg·kg-1·d-1), tigecycline (TIG) positive control group (120 mg·kg-1·d-1), tween saline control group (10 mL·kg-1·d-1) and model group. Results: Bacterial culture revealed: The bacterial clearance rates of CA treatment group were 80%(24/30), 73.33%(22/30), 50.00%(15/30), 46.66%(14/30), 6.66%(2/30) and 10.00%(3/30) in high dose group, middle dose group, low dose group, TIG positive control group, Tween saline negative control group, respectively. CA treatment groups compared with Tween saline negative control group, model group (P<0.001). Compared with TIG positive control group (P<0.05). Pathological sections showed that in the middle and high dose groups of CA, the alveolar structure tended to be normal, and inflammatory cell infiltration was significantly reduced. In the low dose group of CA, the lung tissue was slightly damaged, and there were still inflammatory cell infiltration and abnormal alveolar structure. In the TIG positive control group, the pathological damage of lung tissue was less severe than that in the model group, but a certain degree of inflammatory infiltration and structural disorder were still seen. The survival rate of mice was 80%(24/30) in CA high dose group, 73.33%(22/30) in CA middle dose group, 50.00%(15/30) in CA low dose group, 46.66%(14/30) in TIG positive control group, 6.66%(2/30) in tween negative control group and 10.00%(3/30) in model group. Conclusion: CA group (high and middle dose) has good antibacterial effect and tissue repair effect on acinetobacter baumannii pneumonia in mice, and can significantly improve the survival rate of mice, and CA is better than TIG. This study will provide theoretical basis for the development of new drugs for CA treatment of acinetobacter baumannii pneumonia.

Key words: cinnamaldehyde, acinetobacter baumannii, pneumonia, antibacterial effect, tissue repair effect

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