Maternal High Fat Diet Facilitation The Pressor Effect Of Male Offsprings To Angiotensin II

doi:10.3969/j.issn.2095-1396.2016.03.002

Abstract

Abstract: Objective: To verify maternal rat high fat diet by up-regulating brain renin-angiotensin-system (RAS) to add the sensitivity of adult offspring to angiotensin II (Ang II), facilitation of Ang II induced hypertension. Methods: Adult female SD rats were randomly divided into high fat diet group and standard group, and healthy adult male mating, high fat diet group at 4 weeks before pregnancy, pregnancy and lactation were high fat diet, normal diet group were fed with normal diet in each period, all offspring were divided into two groups: high-fat diet group offspring (OHH) and normal diet group (OCC), the offspring of all offspring were the standard diet after weaning. Measure birth weight of offspring, 3 weeks of age to detect brain the RAS components in lamina terminalise (LT) and paraventricular nucleus (PVN). At 10 weeks of age, the sensitivity of the central nervous system to Ang II was detected in the cerebral ventricle, and the pressor response was observed in Ang II. Results: High fat diet increased the expression of RAS in the brain than the normal diet group, more sensitive pressor effection to intraventricular injection Ang II, and more obvious pressor response to the chronic perfusion Ang II, and the expression of RAS was significantly increased after perfusion. Conclusion: Maternal high fat diet increased the sensitivity of the central nervous system to angiotensin II (Ang II), and facilitated the hypertension induced by Ang II, by means of raising the expression of the ranin-angiotensin-aldosterone-system (RAAS).

Key words: maternal high fat diet, renin-angiotensin-system, hypertension

FANG Zhi-qin, WANG Ya-ling, PENG Wei. Maternal High Fat Diet Facilitation The Pressor Effect Of Male Offsprings To Angiotensin II[J]. ACTA NEUROPHARMACOLOGICA, 2016, 6(3): 8-16.

References

[1] Barker D J. The fetal and infant origins of adult disease [J]. BMJ, 1990, 301(6761): 1111.

[2] Barker D J, Osmond C, Winter P D, et al. Weight in infancy and death from ischaemic heart disease [J]. Lancet, 1989, 334(8663): 577–580.

[3] Barker D J, Osmond C. Diet and coronary heart disease in England and Wales during and after the Second World War[J]. J Epidemiol Community Health, 1986, 40(1): 37–44.

[4] Stein C E, Fall C H, Kumaran K, et al. Fetal growth and coronary heart disease in South India[J]. Lancet, 1996, 348(9037): 1269–1273.

[5] Rebecca M Reynolds, Keith M Allan, Edwin A Raja, et al. Maternal obesity during pregnancy and premature mortality from cardiovascular event in adult offspring: follow-up of 1 323 275 person years[J]. BMJ, 2013, 347: f4539.

[6] World Health Organization. A global brief on hypertension. Silent killer, global public health crisis[C]. Geneva: World Health Organization, 2013.

[7]. Hisashi Masuyama, Yuji Hiramatsu. Effects of a high-fat diet exposure in utero on the metabolic syndrome-like phenomenon in mouse offspring through epigenetic changes in adipocytokine gene expression[J]. Endocrinology, 2012, 153(6): 2823–2830.

[8]. Licio A Velloso. Maternal consumption of high-fat diet disturbs hypothalamic neuronal function in the offspring：implications for the genesis of obesity [J]. Endocrinology, 2012, 153(2): 543-545.

[9]. Dong Mao-long, Zheng Qi-jun, Stephen P Ford, et al. Maternal obesity, lipotoxicity and cardiovascular diseases in offspring[J]. J Mol Cell Cardiol, 2013, 55: 111-116.

[10]. Paul D Taylor, Anne-Maj Samuelsson, Lucilla Poston. Maternal obesity and the developmental programming of hypertension: a role for leptin[J]. ActaPhysiol (Oxf), 2014, 210(3): 508-523.

[11] John Henry Dasinger, Gwendolyn K Davis, Ashley D Newsome, et al. Developmental programming of hypertension: physiological mechanisms [J]. Hypertension, 2016, 68: 826-831.

[12] Cristiane Guberman, Juanita K Jellyman, Han Guang, et al. Maternal high-fat diet programs rat offspring hypertension and activates the adipose renin-angiotensin system [J]. Am J Obstet Gynecol, 2013, 209(3): 262.e1-e8.

[13] Xue Bao-jian, Zhang Zhong-ming, Ralph F Johnson, et al. Sensitization of slow pressor angiotensin II (AngII)-initiated hypertension: induction of sensitization by prior Ang II treatment [J]. Hypertension, 2012, 59(2): 459-466.

[14] Antic V, Kiener-Belforti F, Tempini A, et al. Role of the sympathetic nervous system during the development of obesity-induced hypertension in rabbits [J]. Am J Hypertens, 2000, 13: 556–9.

[15] 郑佳, 肖新华, 张茜, 等. 母代高脂饮食诱导子代在小鼠生命早期出现糖脂代谢紊乱且具有雄性易感性[J]. 中国实验动物学报, 2014, 22(4)：7-11.

[16] Ong K K，Petry C J，Emmett P M，et al．Insulin sensitivity and secretion in normal children related to size at birth, postnatalgrowth，and plasma insulin-like growth factor-I levels [J]．Diabetologia, 2004, 47(6) : 1064-1070．

[17]. Mina Desai, Marie Beall, Michael G Ross. Developmental origins of obesity: programmed adipogenesis[J]. Curr Diab Rep, 2013, 13(1): 27-33.

[18]. Suyeon Kim, Morvarid Soltani-Bejnood, Annie Quignard-Boulange, et al. The adipose renin-angiotensin system modulates systemic markers of insulin sensitivity and activates the intrarenal renin-angiotensin system[J]. J Biomed Biotechnol, 2006, 5: 27012.

[19]. Cassis L A, Saye J, Peach M J. Location and regulation of rat angiotensinogen messenger RNA[J]. Hypertension, 1988, 11(6 Pt 2): 591-596.

[20]. Stefan Engeli, Raymond Negrel, Arya M Sharma. Physiologyand pathophysiology of the adipose tissue renin-angiotensin system[J]. Hypertension, 2000, 35: 1270-1277.

[21]. Xue Bao-jian, Zhang Zhong-ming, Camila Roncari, et al. Aldosterone acting through the central nervous system sensitizes angiotensin II-induced hypertension [J]. Hypertension, 2012, 60(4): 1023-1030.

[22] Thomas Blank, Ingrid Nijholt, Dimitris K Grammatopoulos, et al. Corticotropin-releasing factor receptors couple to multiple G-proteins to activate diverse intracellular signaling pathways in mouse hippocampus: role in neuronal excitability and associative learning [J]. J Neurosci, 2003, 23(2): 700–707.

[23] Meredith Hay, Xue Bao-jian, Alan Kim Johnson AK, et al. Yes! Sex Matters: sex, the brain and blood pressure [J]. Current Hypertension Reports, 2014, 16(1): 458-458.

[24] Alexander Gabor, Frans H H Leenen. Central neuromodulatory pathways regulating sympathetic activity in hypertension [J]. J ApplPhysiol, 2012, 113(8): 1294-1303.

[25] Annette D de Kloet, Davis J Pioquinto, Dan Nguyen, et al. Obesity induces neuroinflammation mediated by altered expression of the renin-angiotensin system in mouse forebrain nuclei [J]. PhysiolBehav, 2014, 136:31-38.

[26] Shun-Guang Wei, Yang Yu, Zhi-Hua Zhang,et al. Proinflammatory cytokines upregulate sympathoexcitatory mechanisms in the subfornical organ of the rat [J]. Hypertension, 2015, 65(5): 1126-1133.

[27] Wei Shun-Guang, Zhang Zhi-Hua, Terry G Beltz, et al. Subfornical organ mediates sympathetic and hemodynamic responses to blood-borne proinflammatory cytokines [J]. Hypertension, 2013, 62(1): 118-125.

[28] Maaike G J Gademan, Manon van Eijsden, Tessa J Roseboom, et al. Maternal prepregnancy body mass index and their children's bloodpressure and resting cardiac autonomic balance at age 5 to 6 years[J]. Hypertension, 2013, 62(3): 641-647.

[29] Ai Nagae, Megumi Fujita, Hiroo Kawarazaki, et al. Sympathoexcitation by oxidative stress in the brain mediates arterial pressure elevation in obesity-induced hypertension [J]. Circulation, 2009, 119(7): 978 –986.

[30] Imran Y Khan, Paul D Taylor, Vasia Dekou, et al. Gender-linked hypertension in offspring of lard-fed pregnant rats [J]. Hypertension, 2003, 41(1):168-175.