ACTA NEUROPHARMACOLOGICA ›› 2020, Vol. 10 ›› Issue (6): 60-63.DOI: 10.3969/j.issn.2095-1396.2020.06.011

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Research Progress on Related Mechanisms of Cerebral Ischemia-Reperfusion Injury

LI Zhao-zhen,ZHANG Dan-shen   

  1. 1. Department of Pharmacy,Hebei North University,Zhangjiakou,075000,China
    2. Hebei University of Science and Technology,Shijiazhuang,050000,China
  • Online:2020-12-26 Published:2020-12-26
  • Contact: 张丹参,女,教授,博士生导师;研究方向:神经药理学;Tel:+86-0313-4029188,E-mail:zhangds2011@126.com
  • About author:李兆珍,女,硕士研究生;研究方向:神经药理学;E-mail:lizhaozhen20212021@126.com
  • Supported by:

    河北省重点研发计划项目生物医药专项(No.20372509D);河北省自然科学基金(No.H2020208032);河北省高等学校科学技 术研究项目(No.ZD2020117);河北省中医药管理局中医药科研计划项目(No.2020268);中央财政公共卫生专项“中药资源普 查项目”(No.Z135080000022)

Abstract:

Cerebral ischemia-reperfusion injury can affect the outcome of the patient’s diseaseeven life-threatening. At presentthe pathogenesis of cerebral ischemia-reperfusion injury includes inflammatory responseexcitatory amino acid toxicityintracellular calcium overloadfree radical damageenergy metabolism disorder and cell apoptosisetc. Many mechanisms influence each other and are complicated. This article summarizes the research on several main mechanisms of cerebral ischemia-reperfusion injury in recent yearsand provides a basis for exploring and improving the research of cerebral ischemia-reperfusion injury.


Key words: cerebral ischemia-reperfusion injury, excitatory amino acid radicals, free radicals, apoptosis

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