ACTA NEUROPHARMACOLOGICA ›› 2020, Vol. 10 ›› Issue (3): 16-20.DOI: 10.3969/j.issn.2095-1396.2020.03.003

Previous Articles     Next Articles

Research Progress of Lidocaine Transdermal Preparations

JIN Shan,ZHANG Dan-shen   

  1. Hebei University of Science and Technology, Shijiazhuang, 050000, China
  • Online:2020-06-26 Published:2021-05-14
  • Contact: 张丹参,女,博士生导师;研究方向:神经药理学;E-mail:zhangds2011@126.com
  • About author:金姗,女,硕士研究生;研究方向:神经药理学;E-mail:154974441@qq.com
  • Supported by:
    河北省重点研发计划项目生物医药专项(20372509D); 河北省自然科学基金(H2020208032);河北省高等学校科学技术研究项
    目(ZD2020117);河北省中医药管理局中医药科研计划项目(2020268);中央财政公共卫生专项“中药资源普查项目”(Z135080000022)

Abstract:

Objective:To explore the research progress of lidocaine transdermal preparations and provide references for the preparation of new,safe and efficient transdermallocal anesthetic preparations required for clinical treatment. Methods:The relevant literatures
of lidocaine transdermal preparations at home and abroad were searched in recent years,and the main dosage forms and characteristics of the transdermal preparations were reviewed. Results: Lidocaine transdermal preparations can increase the transdermal rate,have a rapid onset of action,improve bioavailability,and reduce adverse reactions. The currently retrieved lidocaine dosage forms include creams,gels and other traditional preparations and microemulsions,microemulsion gels,liposomes,alcohol liposomes,film sprays,cataplasms,mesoporous silica nanoparticles. The particles are loaded with new carrier dosage forms such as lidocaine. Conclusion:With the development of new transdermal dosage forms and new technologies, the research results of lidocaine transdermal preparations are expected to be used safely and efficiently in the future.

Key words: lidocaine, transdermal preparation, research progress

CLC Number: