ACTA NEUROPHARMACOLOGICA ›› 2021, Vol. 11 ›› Issue (4): 9-.DOI: 10.3969/j.issn.2095-1396.2021.04.003

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Based on the National Patent Database to Study the Rules of Using Traditional Chinese Medicine Compound Prescriptions for the Treatment of Pulmonary Heart Disease

HU Yong-sheng,WU Chun-xing,WU Ting-yu,WANG Bin,WANG Bo-long   

  1. Yichun UniversityYichun336000China

  • Online:2021-08-26 Published:2021-08-26

Abstract:

ObjectiveBased on data miningto explore medication rules in the treatment of pulmonary heart disease by mining the traditional Chinese medicine compound prescriptions in the national patent databasein order to provide inference for clinical treatment of pulmonary heart disease. MethodsThe related traditional Chinese medicine patent compounds in the national patent database were precisely extractedand the patent compounds meeting the screening criteria entered into Excel 2021 to establish a databasewhich could be used to count the the natureflavor and meridians of traditional Chinese medicine. IBM SPSS Modeler 18.0 and IBM SPSS Statistic 23.0 software were applied to conduct the association rulecluster analysis and factor analysis of high-frequency traditional Chinese medicine. Results80 traditional Chinese medicine patent compounds were finally collectedinvolving 244 traditional Chinese medicinewhich were used 939 times in total. The properties of high-frequency traditional Chinese medicine were mainly warm and coldthe taste was mostly bitter and acridwhile the liver meridian and the heart meridian were the most common. The association rules with high support were Schisandrae Chinensis Fructus-Ginseng Radix et Rhizoma”,“Schisandrae Chinensis Fructus-Ophiopogonis Radix”,“Glycyrrhizae Radix et Rhizoma-Chuanxiong Rhizoma”; the core traditional Chinese medicine mainly included Glycyrrhizae Radix et RhizomaSchisandrae Chinensis FructusAngelicae Sinensis Radix. Cluster analysis obtained 6 types traditional Chinese medicine with potential compatibility relationshipwhile factor analysis extracted 11 common factors. ConclusionIn the treatment of pulmonary heart diseasetonic and astringent medicineblood stasis medicinePhlegm-relieving cough and asthma medicinesuch as Glycyrrhizae Radix et RhizomaSchisandrae Chinensis FructusAstragali RaadixAngelicae Sinensis Radixand Armeniacae Semen Amarum should be chose firstwhat’s morethe therapeutic principles that is to treat phlegm and blood stasis at the same time and co-regulation of qi and blood should be adheredwhich can improve curative effect in clinical.

Key words: pulmonary heart disease, patent, data mining, traditional Chinese medicine compound prescription, compatibility law

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