神经药理学报

神经药理学报 ›› 2025, Vol. 15 ›› Issue (3): 30-.DOI: 10.3969/j.issn.2095-1396.2025.03.005

• 中国实验动物学会2025年实验动物模型标准研讨会 • 上一篇    下一篇

基于“络病理论”探讨辨治脊髓损伤的思路及其血脊髓屏障机制佐证

张星星，梁嘉宇，孙越，温梦昕，钟辉，李强，李亮   

  1. 1. 中医诊断学湖南省重点实验室，湖南中医药大学，长沙，410208，中国 

    2. 中医心肺病证辨证与药膳食疗重点研究室，湖南中医药大学，长沙，410208，中国 

    3. 脊柱外科，湖南省第二人民医院（湖南省脑科医院），长沙，410007，中国

  • 出版日期:2025-06-26 发布日期:2025-07-10
  • 通讯作者: 李亮，教授，博士生导师；研究方向：神经损伤的中医证候生物学基础研究及方剂转化；E-mail：superliliang@126.com
  • 作者简介:张星星，在读硕士；研究方向：神经损伤的中医证候生物学基础研究及方剂转化；E-mail：1169183715@qq.com
  • 基金资助:
    国家自然科学基金面上项目（No.82374323），湖南省自然科学基金面上项目（No.2022JJ30435，No.2024JJ5223），湖南省卫生 健康委科研计划项目（No.C202302087602），湖南省中医药科研计划项目（No.A2023044），湖南中医药大学研究生创新课题 （No.2023CX180，No.2024CX153），湖南中医药大学本科生科研创新基金（No.2023BKS024）

Exploring the Thinking of Differentiation and Treatment of Spinal Cord Injury Based on the Collateral Disease Theory and the Mechanism of the Blood-Spinal Cord Barrier

ZHANG Xing-xing, LIANG Jia-yu, SUN Yue, WEN Meng-xin, ZHONG Hui, LI Qiang, LI Liang   

  1. 1. Hunan Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, 410208, China 

    2. Key Research Office of Syndrome Differentiation of Cardio-Pulmonary Diseases and Medicinal Diet Therapy in TCM, Hunan University of Chinese Medicine, Changsha, 410208, China 

    3. Department of Spinal Surgery, The Second People's Hospital of Hunan Province (Hunan Brain Hospital), Changsha, 410007, China

  • Online:2025-06-26 Published:2025-07-10

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摘要：

脊髓损伤（spinal cord injury，SCI）是由交通事故、高处坠落、运动创伤等因素导致的脊髓结构或功能损 害，临床以运动功能障碍、感觉缺失及二便失司为核心症状，其病理本质涉及神经元坏死、轴突断裂及血脊髓屏 障（blood-spinal cord barrier，BSCB）破坏引发的级联性损伤。当脊髓受到损伤时，会造成感觉丧失、排便排尿困 难等严重后果，极大地影响患者的生活质量。络病学说是中医学体系中的关键组成部分，其核心在于探究络脉 系统的正常生理运作、异常病理表现及其与各类疾病的关联性。该文从络病理论出发，结合BSCB 机制分析脊 髓损伤的发病机制及治疗思路。

关键词: 脊髓损伤, 络病理论, 血脊髓屏障, 理论探讨

Abstract:

Spinal cord injury (SCI) is the damage to the structure or function of the spinal cord caused by factors such as traffic accidents, falls from heights, and sports traumas. Clinically, the core symptoms include motor function impairment, sensory loss, and disorders of defecation and urination. Its pathological essence involves the cascade injury triggered by neuronal necrosis, axonal rupture, and the disruption of the blood-spinal cord barrier (BSCB). When the spinal cord is injured, it will lead to serious consequences such as sensory loss and difficulties in defecation and urination, which greatly affect the quality of life of patients. The collateral disease theory is a crucial component of the traditional Chinese medicine system. Its core lies in exploring the normal physiological operation and abnormal pathological manifestations of the collateral vessel system, as well as its correlations with various diseases. This article starts from the collateral disease theory and combines the BSCB mechanism to analyze the pathogenesis and treatment approaches of spinal cord injury.

Key words: spinal cord injury, collateral disease theory, blood-spinal cord barrier, theoretical discussion

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