神经药理学报 ›› 2020, Vol. 10 ›› Issue (2): 1-.DOI: 10.3969/j.issn.2095-1396.2020.02.001

• 研究论文 •    下一篇

延胡索、乌药、金铃子散、小活络丹对神经病理性疼痛镇痛作用的比较

焦苗苗,王旭,周娜,张梦,刘进娜,谭展望,黄东阳   

  1. 河北医科大学中西医结合学院,石家庄,050011,中国
  • 出版日期:2020-04-26 发布日期:2020-04-26
  • 通讯作者: 黄东阳,博士,讲师;研究方向:分子药理学/ 神经药理学;Tel:+86-0311-86266445,E-mail:dongyang_huang@hotmail.com
  • 作者简介:焦苗苗,本科;研究方向:方- 证相关研究;E-mail:jiaomiao1019@163.com
  • 基金资助:
    2018 年大学生创新性实验计划项目(No.USIP2018003),河北省高等学校科学技术研究项目青年拔尖人才项目(No.BJ2017004),
    河北省自然科学基金优秀青年科学基金(No.C2018206222)

Comparison of Analgesic Effects of Corydalis Yanhusuo,Radix Lindera,Jin Ling-zi powder and Xiao Huo-luo Dan on Rats with Neuropathic Pain#br#

JIAO Miao-miao,WANG Xu,ZHOU Na,ZHANG Meng,LIU Jin-na,TAN Zhan-wang,HUANG Dong-yang   

  1. College of Integrated Chinese and Western Medicine,Hebei Medical University,Shijiazhuang,050011,China
  • Online:2020-04-26 Published:2020-04-26
  • Contact: 黄东阳,博士,讲师;研究方向:分子药理学/ 神经药理学;Tel:+86-0311-86266445,E-mail:dongyang_huang@hotmail.com
  • About author:焦苗苗,本科;研究方向:方- 证相关研究;E-mail:jiaomiao1019@163.com
  • Supported by:
    2018 年大学生创新性实验计划项目(No.USIP2018003),河北省高等学校科学技术研究项目青年拔尖人才项目(No.BJ2017004),
    河北省自然科学基金优秀青年科学基金(No.C2018206222)

摘要:

目的:比较延胡索、乌药、金铃子散、小活络丹对坐骨神经缩窄性损伤(chronic constriction injury,CCI)模型大鼠神经病理性疼痛(neuropathic pain,NP)的镇痛效果。方法:将SD 雄性大鼠随机分为假手术组(n=13)、生理盐水组(n=13)、延胡索组(n=16)、乌药组(n=10)、金铃子散组(n=20)、小活络丹组(n=7),共6 组。采用坐骨神经结扎法造模,于造模后第4 天各组给予相应的药物(延胡索组、乌药组、金铃子散组、小活络丹组大鼠均按剂量12 g·kg-1 给药,假手术组、生理盐水组给予等量生理盐水)灌胃,连续14 天。从开始给药起,每隔1 天测定其热痛阈值。结果:与生理盐水组比较,延胡索、乌药、金铃子散、小活络丹各组大鼠给药后热痛阈值均升高,金铃子散的效果稍微优于延胡索,乌药、小活络丹效果较差。结论:延胡索、乌药、金铃子散、小活络丹对神经病理性疼痛均具有一定的镇痛作用,其中金铃子散的镇痛作用较强且起效快,其次为延胡索,乌药和小活络丹对该种神经病理性疼痛的镇痛效果较不稳定。

关键词: 延胡索, 乌药, 金铃子散, 小活络丹, 神经病理性疼痛, 镇痛

Abstract:

Objective:To compare the analgesic effects of Corydalis Yanhusuo,Radix Lindera,Jin Ling-zi powder and Xiao Huo-luo Dan on chronic neuropathic pain in rats with sciatic nerve chronic constriction injury (CCI). Methods:The male SD rats were randomly divided into 6 groups,sham operation group (n=13),saline group (n=13),Corydalis Yanhusuo group (n=16), Radix Lindera group (n=10),Jin Ling-zi powder group (n=20) and Xiao Huo-luo Dan group (n=7),respectively. Four days after the CCI surgery,the drugs were given by intragastric administration. The rats in Corydalis Yanhusuo group,Radix Lindera group,Jin Ling-zi powder group and Xiao Huo-luo Dan group were given 12 g·kg-1 drug respectively. The sham operation group and saline group were given the same amount of saline. The rats were administered intragastrically once a day for 14 consecutive days. From the beginning of the administration,the threshold of thermal pain was measured every other day by hot needling instrument. Results:Compared with Control group,the thermal threshold of Corydalis Yanhusuo group,Radix Lindera group,Jin Ling-zi powder group and Xiao Huo-luo Dan group were all increased,but the increase of Corydalis Yanhusuo group and Jin Ling-zi powder group were more significantly. Conclusion:Corydalis Yanhusuo,Radix Lindera,Jin Ling-zi powder and Xiao Huo-luo Dan all have analgesic effect on neuropathic pain,among which Jin Ling-zi powder has the strongest analgesic effect and the
fastest curative effect,followed by Corydalis Yanhusuo. The analgesic effects of Radix Lindera and Xiao Huo-luo Dan were not stable.

Key words: Corydalis Yanhusuo, Radix Lindera, Jin Ling-zi powder, Xiao Huo-luo Dan, neuropathic pain, analgesia