基于光学时轴校准MRI数据重建的高时空分辨率神经成像

摘要/Abstract

摘要： 功能核磁共振成像是一种重要的生物医学成像和神经科学研究的手段。然而，空间分辨率低、时间分辨率低以及信噪比低仍然限制了其实际研究应用。本文提出了一种高时空分辨率的图像重建方法，实现光信息同步磁共振技术扫描脑皮层神经活动产生的血氧动态响应，时分式覆盖k空间数据(time division coverage, TDC)。同时也提出一种波长参数化指数平均滤波波长调制光谱法（PEMA-WMS）实现实时脑皮层血氧动态光学传感。实验给出了在预实验磁共振图像作为高空间分辨率组织层的光子流传感蒙特卡罗模拟方法和视觉皮层功能成像仿真，并得出本文方法的图像重建结果。

关键词: 高时空分辨率, 磁共振成像, 图像重建, 光学传感, 时轴校准, 波长调制光谱法

Abstract: Functional magnetic resonance imaging is a powerful tool for biomedical imaging and neuroscience research. However, its practical utility is still rather limited due to poor spatial resolution, poor temporal resolution and low signal-to-noise ratio. In this paper, we proposed a new technique that enabled reconstruction of MRI scan data with optic collaborative sensing and realized high spatial resolution and high temporal resolution enhancement. For a specific task, a hemodynamic response in cortex related to neural activity could be scanned multiple times synchronized by optic sensing detection, and achieved time division coverage (TDC) of k-space data. Also, we presented a wavelength modulation spectroscopy with parametric exponential moving average (PEMA-WMS) method to realize real-time optic sensing in our proposed scheme. We illustrate the performance of this method with images of visual cortex functional imaging simulation with the Monte Carlo Modeling of light transport in pre-experimental MRI data phantom tissues.

Key words: high temporal-spatial resolution, magnetic resonance imaging, image reconstruction, optic sensing, temporal calibration, Wavelength Modulation Spectroscopy

中图分类号:

R445.2

邓梁，史仪凯，张均田. 基于光学时轴校准MRI数据重建的高时空分辨率神经成像[J]. 神经药理学报, 2011, 1(3): 47-54.

Deng Liang, Shi Yi-Kai, Zhang Jun-Tian . High Temporal-spatial Resolution Neuroimaging Method Based on Reconstruction of MRI Scan Data with Optic-sensing Temporal Calibration[J]. Acta Neuropharmacologica, 2011, 1(3): 47-54.

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