结肠腺瘤性息肉病蛋白在大脑皮层早期发育中的作用

摘要/Abstract

摘要： 结肠腺瘤性息肉病（adenomatous polyosis coli，APC）蛋白是一个大型的多功能蛋白，在发育的大脑皮层中，增殖的细胞可以表达 APC，且当细胞向皮层板迁移的时候它的表达会增加。其对于 Wnt/β-catenin 信号，细胞骨架动态以及细胞极性十分重要。本文对 APC 在大脑皮层早期发育中的作用进行了总结。APC 在大脑皮层早期发育过程中是调节细胞数目，核迁移运动，细胞极性以及细胞类型的特化所必须的。

关键词: 结肠腺瘤性息肉病, 皮层发育, 神经发生, Wnt信号

Abstract: Adenomatous polyosis coli（APC）is a large multifunctional protein known to be important for Wntβ-catenin signalling, cytoskeletal dynamics, and cell polarity. In the developing cerebral cortex, APC is expressed in proliferating cells and its expression increases as cells migrate to the cortical plate. In this article, we summarized the roles of APC in the early developing cerebral cortex. APC is required for multiple aspects of early cerebral cortical development, including the regulation of cell number, interkinetic nuclear migration, cell polarity, and cell type specification.

中图分类号:

R735.35

左玮, 季晖, 王文. 结肠腺瘤性息肉病蛋白在大脑皮层早期发育中的作用[J]. 神经药理学报, 2011, 1(2): 42-47.

ZUO Wei, JI Hui, WANG Wen. Roles of Adenomatous Polyosis Coli in the Early Developing Cerebral Cortex[J]. ACTA NEUROPHARMACOLOGICA, 2011, 1(2): 42-47.

参考文献

1. Nuno Sousa, Joao J.Cerqueira, Osborne F.Almeida. Corticosteroid receptors and neuroplasticity[J]. Brain Res Rev, 2008, 57(2): 561-570.

2. 朱晓华, 薄涛. 发育中脑内糖皮质激素受体表达及作用的研究进展[J]. 中国当代儿科杂志, 2007, 9(3): 278-280.

3. Stephanie Ridder, Sabine Chourbaji, Rainer Hellweg, et al. Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions[J]. J Neurosci, 2005, 25 (26): 6243-6250.

4. Francesca Marini, Chiara Pozzato, Valentino Andreetta, et al. Single exposure to social defeat increases corticotropin-releasing factor and glucocorticoid receptor mRNA expression in rat hippocampus[J]. Brain Res, 2006, 1067 (1): 25-35.

5. Tamura G, Olson D, Miron J,et al. Tolloid-like 1 is negatively regulated by stress and glucocorticoids[J]. Brain Res, 2005, 142 (2) : 81-90.

6. 林蕾，张良成，郭永正. 突触可塑性及相关物质的研究进展[J]. 中华全科医学，2009, 7(9): 995-996.

7. Lu Yuan, Kimberly Christian, Lu Bai. BDNF: a key regulator for protein synthesis－dependent LTP and long-term memory[J]. Neurobiol Learn Mem, 2008, 89(3): 312-323.

8. Dranovsky A, Hen R. Hippocampal neurogenesis: regulation by stress and antidepressants[J]. Biol Psych, 2006, 59(12): 1136-1143.

9. 马楼艳, 柴李殷, 肖谦. 脑源性神经营养因子与脑功能[J]. 国际老年医学杂志, 2010, 31(3): 110-113.

10. Kazunori Kanemaru, Yohei Okubo, Kenzo Hirose,et al. Regulation of neurite growth by spontaneous Ca2+ oscillations in astrocytes[J]. J Neurosci, 2007, 27(33): 8957-8966.

11. 姜雪，刘航，杜志成. 星形胶质细胞在调节突触可塑性中的作用[J]. 中国实用医药，2011, 6(14): 237-238.

12. Pascal Jourdan, Linda H Bergersen, Khaleel Bhaukaurally, et al. Glutamate exocytosis from astrocytes controls synaptic strength[J]. Nat Neurosci, 2007, 10 (3): 331-339.

13. Gertrudis Perea, Alfonso Araque. Astrocytes potentiate transmitter release at single hippocampal synapses[J]. Science, 2007, 317 ( 5841) : 1083-1086.

14. Song Hongjun, Charles F.Stevens, Fred H.Gage. Astroglia induce neurogenesis from adult neural stem cells[J]. Nature, 2002, 417 (6884) : 39-44.

15. 王立芹, 赵久红, 唐源远,等. 星形胶质细胞条件培养液促进新生大鼠海马神经干细胞分化[J]. 解剖科学进展, 2009, 15(3): 265-268.

16. Basam Z. Barkho, Song Hongjun, James B.Amone, et al. Identification of astrocyte-expressed factors that modulate neural stem/ progenitor cell differentiation[J]. Stem CellsDev, 2006, 15(3): 407-421.

17. Ethan G Hughes, Jamie L Maguire, Melanie T McMinn,et al. Loss of glial fibrillary acidic protein results in decreased glutamate transport and inhibition of PKA-induced EAAT2 cell surface trafficking[J]. Brain Res Mol Brain Res, 2004, 124(2): 114-123.

18. Mounira Banasr, Ronald S.Duman. Glial loss in the prefrontal cortex is sufficient to induce depressive-like behaviors[J]. Biol Psychiatry, 2008, 64(10): 863-870.

19. Boldizsár Czéh, Maria Simon, Barthel Schmelting, et al.Astroglial plasticity in the hippocampus is affected by chronic psychosocial stress and concomitant fluoxetine treatment[J]. Neuropsychopharmacology, 2006, 31(8): 1616-1126.

20. Robert M.Sapolsky, Lewis C.Krey, Bruce S.McEwen. Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging[J]. J Neurosci, 1985, 5(5): 1221-1227.

21. Marina Cerseto, Analia Reinés, Alejandro Ferrero,et al. Chronic treatment with high doses of corticosterone decreases cytoskeletal proteins in the rat hippocampus[J]. Eur J Neurosci, 2006, 24(12), 3354-3364.

22. Zhao Yuanan, Xie Weidong, Dai Jianguo, et al. The varying effects of short-term and long-term corticosterone injections on depression-like behavior in mice[J]. Brain Res, 2009, 1261: 82-90.

23. Despina A.Tata, Veronica A.Marciano, Brenda J.Anderson. Synapse loss from chronically elevated glucocorticoids: relationship to neuropil volume and cell number in hippocampal area CA3[J]. J Comp Neurol, 2006, 498(3): 363-374.

24. 王中立, 戴建国, 陈琳, 等. 人参拮抗高皮质激素血症致神经元损伤的作用[J]. 中国实验方剂学杂志，2010, 16(16): 94-98.

25. Alfarez DN, De Simoni A, Velzing EH, et al. Corticosterone reduces dendritic complexity in developing hippocampal CA1 neurons[J]. Hippocampus, 2009, 19(9): 828-836.

26. Marain Joëls, Harm J.Krugers. LTP after stress: up or down? [J] Neural Plasticity, doi: 10.1155/2007/93202.

27. 赵云, 杨发青, 王新兴,等. 应激对机体脑体功能的影响及其生物学机制初探[J]. 中国应用生理学杂志, 2009, 25(2): 166-170.

28. Fraser Murray, David W.Smith, Peter H.Hutson. Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice[J]. Eur J Pharmacol, 2008, 583(1): 115-127.

29. Xu Z, Zhang Y, Hou B,et al. Chronic corticosterone administration from adolescence through early adulthood attenuates depression-like behaviors in mice[J]. J Affect Disord, 2011, 131(1-3): 128-135.

30. James P.O’Callaghan, Roberta E.Brinton, Bruce S.McEwen. Glucocorticoids regulate the concentration of flial fibrillary acidic protein throughout the brain[J]. Brain Res, 1989, 494(1):159-161.

31. James P.O’Callaghan, Roberta E.Brinton, McEwen BS. Glucocorticoids regulate the synthesis of flial fibrillary acidic protein in intact and adrenalectomized rats but do not affect its expression following brain injury[J]. J Neurochem, 1991, 57(3):860-869.

32. Stephane Martin, Jeremy M.Henley, David Holman, et al. Hoogenraad, Harmer J.Krugers. Corticosterone alters AMPAR mobility and facilitates bidirectional synaptic plasticity[J]. PloS One, 2009, 4(3): 1-8.

33. Eric A.Stone, Yan Lin. An anti-immobility effect of exogenous corticosterone in mice[J]. Eur J Pharmacol, 2008, 580(1-2): 135-142.

34. Chang Chennen, Jen-Tsung Yang , Lee Tsong-Hai, et al. Dexamethasone enhances upregulation of nerve growth factor mRNA expression in ischemic rat brain[J]. J Clin Neurosci, 2005, 12(6): 680-684.

35. He Wenbin, Zhao Ming, Machida Takeo, et al. Effect of corticosterone on developing hippocampus: short-term and long-term outcomes[J]. Hippocampus, 2009, 19(4): 338-349

36. Yang CH, Huang CC, Hsu KS. Behavioral stress modifies hippocampal synaptic plasticity through corticosterone-induced sustained extracellular signal-regulated kinase/mitogen -activated protein kinase activation[J]. J Neurosci, 2004, 24(49): 11029-11034.

37. Krugers HJ, Goltstein PM, van der Linden S, et al. Blockade of glucocorticoid receptors rapidly restores hippocampal CA1 synaptic plasticity after exposure to chronic stress[J]. Eur J Neurosci, 2006, 23(11): 3051-3055.

38. Theodore C.Dumas, Todd Gillette , Deveroux Ferguson , et al . Anti-glucocorticoid gene therapy reverses the impairing effects of elevated corticosterone on spatial memory, hippocampal neuronal excitability, and synaptic plasticity[J]. J Neurosci, 2010, 30(5):1712-1720.

39. Walesiuk A, Braszko JJ. Preventive action of Ginkgo biloba in stress- and corticosterone-induced impairment of spatial memory in rats[J]. Phymedicine, 2009, 16(1): 40-46.

40. Anna Walesiuk, Jan J Braszko . Gingkoselect alleviates chronic corticosterone-induced spatial memory deficits in rats[J]. Fitoterapia, 2010, 81(1): 25-29.

41. Andrea Gregus , Amanda J Wintink, Alicia C Davis, et al. Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats[J]. Behav Brain Res, 2005, 156(1):105-114.

42. Zhao Yunan, Ma Ru, Shen Jia, et al. A mouse model of depression induced by repeated corticosterone injections[J]. Eur J Pharmacol, 2008, 581(1-2): 113-120.

43. Wendie Marks, Neil M Fournier, Lisa E Kalynchuk . Repeated exposure to corticosterone increases depression-like behavior in two different versions of the forced swim test without altering nonspecific locomotor activity or muscle strength[J]. Physiol Behav, 2009, 98(1-2): 67-72.

44. Michihiko Iijima, Akie Ito, Shinsuke Kurosu,et al. Pharmacological characterization of repeated corticosterone injection-induced depression model in rats[J]. Brain Res, 2010, 1359: 75-80.

45. Bombi Lee, Insop Shim, Hye-Jung Lee, et al. Effects of acupuncture on chronic corticosterone-induced depression-like behavior and expression of neuropeptide Y in the rats[J]. Neurosci Lett, 2009, 453(3): 151-156.

46. Huang Zhen, Zhong XiaoMing, Li ZhaoYi, et al. Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats[J]. Neurosci Lett, 2011, 493(3): 145-148.

47. Wang Zhongli, Dai Jianguo, Chen Lin, et al. Preventive action of Panax ginseng roots in hypercortisolism-induced impairment of hippocampal neurons in male C57BL/6N mice[J]. Phytother Res, 2011, 25(8):1242-1245.

48. Laura Musazzi , Giorgio Racagni, Maurizio Popoli . Stress, glucocorticoids and glutamate release: effects of antidepressant drugs[J]. Neurochem Int, 2011, 59(2): 138-149.

49. Ozawa S. Role of glutamate transporters in excitatory synapses in cerebellar Purkinje cells[J]. Brain Nerve, 2007, 59(7): 669 -676.

50. 疏树华, 方才. 兴奋性氨基酸及受体与脑损伤的研究进展[J]. 立体定向和功能性神经外科杂志, 2007, 20(2): 124-126.

51. 鄂晓, 张英鸽. 成年海马中神经发生及影响因素[J]. 生物技术通讯, 2010, 21(3): 443-448.

52. 陈琳, 赵玉男, 戴建国,等. 海马cAMP反应元件结合蛋白与抗抑郁治疗[J]. 生理学报, 2010, 62(6): 489-494.

53. Yogesh Dwivedi . Brain-derived neurotrophic factor: role in depression and suicide[J]. Neuropsychiatr Dis Treat, 2009, 5: 433-449.

54. Alana Conti, John F. Cryan, Ashutosh Dalvi, et al. cAMP response element-binding protein is essential for the up regulation of brain-derived neurotrophic factor transcription, but not the behavioral or endocrine responses to antidepressant drugs[J]. J Neurosci, 2002, 22(8): 3262-3268.

55. Shannon L.Gourley, Florence J.Wu, Drew D. Kiraly ,et al. Regionally-specific regulation of ERK1/2 MAPkinase in a model of antidepressant-sensitive chronic depression[J]. Biol Psychiatry, 2008, 63(4): 353-359.

56. Chi Hsien Peng, Shih Hwa Chiou , Shin Jen Chen, et al. Neuroprotection by Imipramine against lipopolysaccharide-induced apoptosis in hippocampus-derived neural stem cells mediated by activation of BDNF and the MAPK pathway[J]. Eur Neuropsychopharmacol, 2008, 18(2): 128-140.

57. 戴建国, 陈琳, 赵玉男,等. 基于星形胶质细胞靶点的抑郁症发病机制研究进展[J]. 中国药理学通报, 2010, 26(9): 1132-1135.

58. Zhao Yuanan, Shen Jia, Su Hui, et al. Chronic corticosterone injections induce a decrease of ATP levels and sustained activation of AMP-activated protein kinase in hippocampal tissues of male mice[J]. Brain Res, 2008, 1191: 148-156.

59. Zhao Yunan, Shen Jia, Su Hui, et al. Long-term exposure to high corticosterone levels inducing a decrease of adenylate kinase 1 activity[J]. Tsinghua Science and Technology, 2009, 14(4): 519-527.

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